Highly　dispersed　single　metal　atom　or　cluster　catalysts　have　attracted　increasing　attention　because　of　improved　atomic　efficiency,　higher　reactivity　and　better　selectivity.　However,　these　catalysts　on　oxide　supports　often　sinter　to　form　large　particles　at　high　temperatures,　which　can　lead　to　reduced　surface　areas　and　decreased　catalytic　activities,　and　are　a　major　challenge　to　the　development　of　optimal　low　temperature-active　and　sinter-resistant　catalysts.　Two　kinds　of　platinum　(Pt)　clusters　on　titanium　dioxide　(TiO2)　supports　are　successfully　prepared　in　this　study　to　investigate　the　low　temperature　activity　towards　carbon　monoxide　(CO)　oxidation　as　well　as　thermal　stability　of　the　resulting　catalyst;　highly　oxidized　Pt　clusters　demonstrated　higher　catalytic　activity　and　thermal　stability　towards　CO　oxidation　as　compared　with　lower　oxidized　Pt　clusters,　since　the　high　oxidation　state　of　the　catalytic　metal　active　sites　is　believed　to　be　highly　correlated　with　the　electronic　metal-support　interactions　(EMSI)　between　Pt　and　TiO2　support,　and　the　results　suggest　that　EMSI　tailors　the　unoccupied　5d　state　of　Pt　species,　thus　greatly　leading　to　the　high　activity　and　thermal　stability.