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作者:

Ruan, Xiaogang (Ruan, Xiaogang.) | Wang, Jinlian (Wang, Jinlian.) | Li, Hui (Li, Hui.) | Li, Xiaoming (Li, Xiaoming.)

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摘要:

We introduce a method for modeling cancer diagnosis at the molecular level using a Chinese microarray gastric cancer dataset. The method combines an artificial neural network with a decision tree that is intended to precede standard techniques, such as classification, and enhance their performance and ability to detect cancer genes. First, we used the relief algorithm to select the featured genes that could unravel cancer characteristics out of high dimensional data. Then, an artificial neural network was employed to find the biomarker subsets with the best classification performance for distinguishing cancerous tissues and their counterparts. Next a decision tree expression was used to extract rules subsets from these biomarker sets. Rules induced from the best performance decision tree, in which the branches denote the level of gene expression, were interpreted as a diagnostic model by using previous biological knowledge. Finally, we obtained a gastric cancer diagnosis model for Chinese patients. The results show that using the Chinese gastric biomarker genes with the diagnostic model provides more instruction in biological experiments and clinical diagnosis reference than previous methods.

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作者机构:

  • [ 1 ] [Ruan, Xiaogang]Beijing Univ Technol, Coll Elect Informat & Control Engn, Beijing, Peoples R China
  • [ 2 ] [Wang, Jinlian]Beijing Univ Technol, Coll Elect Informat & Control Engn, Beijing, Peoples R China
  • [ 3 ] [Li, Hui]Beijing Univ Technol, Coll Comp Sci, Beijing, Peoples R China
  • [ 4 ] [Li, Xiaoming]Lang Fang Normal Univ, Hebei, Peoples R China

通讯作者信息:

  • [Ruan, Xiaogang]Beijing Univ Technol, Coll Elect Informat & Control Engn, Beijing, Peoples R China

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来源 :

2008 IEEE CONGRESS ON EVOLUTIONARY COMPUTATION, VOLS 1-8

年份: 2008

页码: 1051-,

语种: 英文

被引次数:

WoS核心集被引频次: 1

SCOPUS被引频次: 1

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

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