The　widespread　occurrence　of　organic　micmpollutants　(OMPs)　in　water　has　serious　effects　on　the　environment　and　human　health.　Recently,　reverse　osmosis　(RO)　membrane　technology　has　been　used　for　resolving　this　emerging　concern,　and　the　state-of-the-art　polyamide　RO　membranes　are　normally　fabricated　by　the　interfacial　polymerization　method.　Further　reducing　the　energy　consumption　and　operation　cost,　developing　high-performance　polyamide　RO　membranes　will　be　the　key　for　resolving　the　issue　of　effective　removal　of　OMPs.　Herein,　a　new　strategy　is　proposed　for　fabricating　robust　and　high-efficient　polyamide　RO　membranes　via　the　self-assembled　aromatic　nanoparticles　(SANs)　controlled　interfacial　polymerization　(SANCIP)　method.　The　membrane　surface　characteristics　and　interior　microstructures　of　polyamide　layer　could　be　conveniently　manipulated　by　regulating　the　SAN　nanoparticles　size　and　content.　The　SANs　tuned　polyamide　membrane　(PAMSAN)　with　asymmetric　structure,　e.g.,　much　looser　and　crumpled　front　surface　and　much　denser　and　smooth　rear　surface,　exhibits　ultra-high　water　flux　similar　to　67.8　L　.m(-2)　.h(-1)　and　satisfactory　NaCl　rejection　(＞98.3%),　as　well　as　very　high　OMPs　rejection　(＞99.4%).　Moreover,　the　PAM-SAN　membrane　has　good　stability　and　anti-fouling　performance　in　long-term　RO　running　process.　This　facile　and　cost-effective　strategy　provides　a　useful　guideline　in　designing　high-performance　polyamide　membranes　with　a　vast　potential　in　the　removal　of　OMPs　for　advanced　water　treatment.