Because　of　the　vulnerability　of　roof　sheathing　panel　to　wind　load,　light-frame　wood　low-rise　buildings　often　suffer　from　serious　destructions　in　typhoon　hazards.　Efficient　assessment　of　these　hazards　is　an　urgent　need　for　the　purpose　of　risk　mitigation.　The　paper　develops　a　database-assisted　fragility　approach　for　the　assessment　of　typhoon-induced　hazards　to　low-rise　building　roofing.　In　the　developed　approach,　the　failure　of　a　single　panel　and　the　damage　ratio　of　the　entire　roof　over　the　typhoon　duration　are　formulated　in　a　probabilistic　way　where　the　dependence　among　wind　loads　is　considered.　Via　the　probabilistic　formulation,　the　holistic　analysis　for　typhoon-induced　hazards　to　low-rise　building　roofs　is　decomposed　to　the　hazard　analysis　at　each　individual　time　step.　An　analytical　solution　is　proposed　to　determine　the　failure　probability　of　each　single　panel　and　the　probability　related　to　the　associated　failure　of　each　pair　of　panels　at　each　time　step.　For　a　single　panel,　its　failure　probability　is　estimated　by　applying　the　Hermite　transformation　to　the　limit-state　function.　For　the　associated　failure　of　each　pair　of　panels,　Nataf　transformation　is　used　to　model　the　dependence　between　the　limit-state　functions　of　two　panels.　Wind　field　data　recorded　during　the　historical　typhoon　Hagupit　are　used　to　illustrate　the　effectiveness　of　the　approach.　Through　this　approach,　the　damage　progress　on　roofs　is　revealed　and　the　influence　of　wind　loading　dependence　is　investigated.　(C)　2021　American　Society　of　Civil　Engineers.