The　seismic　vulnerability　of　cable-stayed　bridges　located　in　seismically　active　regions　can　be　of　great　concern　to　the　regional　safety　and　resilience.　A　promising　design　practice　for　cable-stayed　bridges　lies　in　decoupling　the　deck　from　deck-pylon　connection　and　incorporating　energy　dissipation　devices　to　reduce　the　dynamic　responses.　In　this　study,　the　performance-based　seismic　design　(PBSD)　procedure　is　adapted　to　the　optimal　design　of　damper　devices　at　the　deck-pylon　connections　in　a　benchmark　cable-stayed　bridge.　The　benchmark　cable-stayed　bridge　was　modeled　in　the　OpenSees　platform,　which　was　calibrated　against　the　previous　finite　element　models.　Then　it　was　seismically　designed　with　viscous　and　metallic　dampers　in　the　longitudinal　and　transverse　direction,　respectively.　The　component-level　fragility　functions　of　the　cable-stayed　bridge　were　first　derived　based　upon　the　multiple　stripe　analysis　(MSA)　method,　and　then　the　system-level　repair　cost　ratio　(RCR)　surfaces　were　built　under　the　PBSD　framework.　Finally,　the　genetic　algorithm　based　on　parallel　computation　was　utilized　to　identify　the　optimal　parameters　of　the　damper　devices.　The　analysis　results　illustrate　that　the　optimal　design　parameters　can　be　effectively　obtained　through　the　proposed　method,　and　the　damper　devices　with　optimal　parameters　lead　to　a　significant　reduction　of　the　overall　repair　cost.　The　study　also　demonstrates　that　if　the　device　parameters　are　not　selected　appropriately,　the　dampers　can　have　negative　effects　on　bridge　responses.　The　design　framework　and　the　findings　could　provide　the　guidance　for　the　designing　and　retrofitting　of　cable-stayed　bridges　in　practice.