To　study　the　changes　of　the　pressure　waveform　in　a　large　artery,　a　fluid-wall　interaction　model　was　constructed　and　the　finite　element　method　was　employed.　The　numerical　results　indicate　that　the　pressure　wave　is　reflected　and　the　peak　pressure　gradually　increases.　The　changes　of　the　pressure　waveform　in　a　large　artery　were　simulated　successfully.　The　results　are　in　agreement　with　physiological　facts.　The　model　can　be　used　to　investigate　other　mechanical　properties　of　arteries　in　future.