LINC00958 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of oesophageal squamous cell carcinoma cells. - 文章详情页

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Oesophageal　cancer　is　one　of　the　deadliest　cancers　in　the　world.　Oesophageal　squamous　cell　carcinoma　(ESCC)　is　the　most　prevalent　histological　type　of　oesophageal　cancer.　Oesophageal　cancer　has　a　poor　prognosis　because　of　its　invasiveness.　Thus,　it　is　especially　important　to　seek　effective　treatment　methods.　Research　indicates　that　long　non-coding　RNAs　(lncRNAs)　play　a　significant　role　in　the　occurrence　and　development　of　oesophageal　cancer.　The　aim　of　this　study　was　to　describe　the　role　of　LINC00958　in　ESCC.　Bioinformatics　and　real-time　quantitative　polymerase　chain　reaction　(RT-qPCR)　methods　were　utilized　to　predict　and　verify　the　expression　of　LINC00958　in　ESCC.　Related　functional　experiments,　including　cell　proliferation,　migration　and　invasion,　were　performed.　In　addition,　a　western　blot　and　a　dual　luciferase　reporter　gene　experiment　were　used　to　study　the　detailed　carcinogenic　mechanism　of　LINC00958.　The　results　indicated　there　was　a　high　expression　of　LINC00958　in　ESCC,　which　promoted　proliferation,　migration,　invasion　and　Epithelial-Mesenchymal　Transition　(EMT)　of　ESCC　cells,　and　this　effect　may　be　via　regulating　miR-510-5p.

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[ 1 ] [Wang Biqi]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Faculty of environment and life, Beijing University of Technology, Beijing, China
[ 2 ] [Tang Duo]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Faculty of environment and life, Beijing University of Technology, Beijing, China
[ 3 ] [Liu Zijia]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Faculty of environment and life, Beijing University of Technology, Beijing, China
[ 4 ] [Wang Qian]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Faculty of environment and life, Beijing University of Technology, Beijing, China
[ 5 ] [Xue Shan]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Faculty of environment and life, Beijing University of Technology, Beijing, China
[ 6 ] [Zhao Zijie]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Faculty of environment and life, Beijing University of Technology, Beijing, China
[ 7 ] [Feng Dongdong]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Faculty of environment and life, Beijing University of Technology, Beijing, China
[ 8 ] [Sheng Chao]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Faculty of environment and life, Beijing University of Technology, Beijing, China
[ 9 ] [Li Jintao]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Faculty of environment and life, Beijing University of Technology, Beijing, China
[ 10 ] [Zhou Zhixiang]Beijing International Science and Technology Cooperation Base of Antivirus Drug, Faculty of environment and life, Beijing University of Technology, Beijing, China

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