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作者:

Yang Chunlan (Yang Chunlan.) | Ren Jiechuan (Ren Jiechuan.) | Li Wan (Li Wan.) | Lu Min (Lu Min.) | Wu Shuicai (Wu Shuicai.) (学者:吴水才) | Chu Tongpeng (Chu Tongpeng.)

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摘要:

In patients with Alzheimer's Disease (AD), the hippocampal network has been extensively investigated in previous studies; however, little is known about the morphological network associated with the hippocampus in the AD patients. A total of 68 patients with AD and another 68 gender and age matched healthy subjects were studied. Individual-level morphological hippocampal networks were constructed based on volume and texture features extracted from MRI to study the connections between bilateral hippocampus and 11 other subcortical gray matter structures. The relationship between morphological connections and Mini-Mental State Examination (MMSE) scores was also studied. Connections between bilateral hippocampus and bilateral thalamus, bilateral putamen were significant differences between the AD patients and controls (p < 0.05). There were significantly different in bilateral hippocampal connectivity, and for the left hippocampus, the connection to the right caudate were found to be statistically significant. The morphological connections between left hippocampus and bilateral thalamus (left: R = 0.371, p < 0.001; right: R = 0.411, p < 0.001), bilateral putamen (left: R = 0.383, p < 0.001; right: R = 0.348, p < 0.001), right hippocampus and bilateral thalamus (left: R = 0.370, p < 0.001; right: R = 0.387, p < 0.001), left putamen (R = 0.377, p < 0.001) were significantly positively correlated with the MMSE scores. Similar patterns were observed for left and right hippocampal connectivity and the connections highly associated with MMSE scores were also within the abnormal connections in AD patients.

关键词:

Alzheimer’s disease Cognitive Morphological hippocampal networks

作者机构:

  • [ 1 ] [Yang Chunlan]Department of Environment and Life, Beijing University of Technology, Beijing 100020, China
  • [ 2 ] [Ren Jiechuan]Department of Epilepsy, Neurology Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
  • [ 3 ] [Li Wan]Department of Environment and Life, Beijing University of Technology, Beijing 100020, China
  • [ 4 ] [Lu Min]Department of Environment and Life, Beijing University of Technology, Beijing 100020, China
  • [ 5 ] [Wu Shuicai]Department of Environment and Life, Beijing University of Technology, Beijing 100020, China
  • [ 6 ] [Chu Tongpeng]Department of Radiology, Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao University, Yantai, Shandong 264000, China. Electronic address: chutongpeng@163.com

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来源 :

Brain and cognition

ISSN: 1090-2147

年份: 2021

卷: 151

页码: 105748

2 . 5 0 0

JCR@2022

ESI高被引阀值:7

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WoS核心集被引频次: 0

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ESI高被引论文在榜: 0 展开所有

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