Traditional　enhanced　external　counterpulsation　(EECP)　used　for　the　clinical　treatment　of　patients　with　coronary　heart　disease　only　assesses　diastolic/systolic　blood　pressure　(Q　=　D/S　＞　1.2).　However,　improvement　of　the　hemodynamic　environment　surrounding　vascular　endothelial　cells　of　coronary　arteries　after　long-term　application　of　EECP　is　the　basis　of　the　treatment.　Currently,　the　quantitative　hemodynamic　mechanism　is　not　well　understood.　In　this　study,　a　standard　0D/3D　geometric　multi-scale　model　of　the　coronary　artery　was　established　to　simulate　the　hemodynamic　effects　of　different　counterpulsation　modes　on　the　vascular　endothelium.　In　this　model,　the　neural　regulation　caused　by　counterpulsation　was　thoroughly　considered.　Two　clinical　trials　were　carried　out　to　verify　the　numerical　calculation　model.　The　results　demonstrated　that　the　increase　in　counterpulsation　pressure　amplitude　and　pressurization　duration　increased　coronary　blood　perfusion　and　wall　shear　stress　(WSS)　and　reduced　the　oscillatory　shear　index　(OSI)　of　the　vascular　wall.　However,　the　impact　of　pressurization　duration　was　the　predominant　factor.　The　results　of　the　standard　model　and　the　two　real　individual　models　indicated　that　a　long　pressurization　duration　would　cause　more　hemodynamic　risk　areas　by　resulting　in　excessive　WSS,　which　could　not　be　reflected　by　the　change　in　the　Q　value.　Therefore,　long-term　pressurization　during　each　cardiac　cycle　therapy　is　not　recommended　for　patients　with　coronary　heart　disease　and　clinical　treatment　should　not　just　pay　attention　to　the　change　in　the　Q　value.　Additional　physiological　indicators　can　be　used　to　evaluate　the　effects　of　counterpulsation　treatment.