In　this　study,　the　combination　effect　of　preozonation　and　carbon　nanotubes　(CNTs)　layer　modification　on　lowpressure　membrane　(LPM)　fouling　control　was　systematically　investigated.　To　understand　the　alleviation　mechanism　of　the　hybrid　process,　natural　organic　matter　(NOM)　from　IHSS　and　effluent　organic　matter　(EfOM)　from　actual　sewage　effluent　were　both　selected　as　the　typical　organic　foulants　presented　in　actual　surface　water　and　wastewater.　A　dead-end　continuous　flow　model　combined　with　programmable　logic　control　system　was　used　to　operate　four　membrane　filtration　units　and　their　backwash　processes.　With　a　constant　permeates　flux,　the　fouling　resistant　of　CNT　modified　LPM　after　preozonation　could　be　evaluated　according　to　the　increase　in　transmembrane　pressure　(TMP).　The　results　revealed　that　the　hybrid　approach　of　preozonation　and　CNTs　modification　could　significantly　improve　the　anti-fouling　ability　of　LPM,　reduce　the　backwash　frequency,　and　improve　the　reversibility　of　membrane　fouling.　During　the　filtration　of　EfOM　and　NOM,　preozonation　improved　the　water　treatment　capacity　of　the　CNTs　modified　membranes.　The　experiment　of　mass　balance　revealed　that　preozonation　enhanced　the　recoverability　of　CNTs　modified　membrane　and　greatly　increased　its　operation　time　in　treating　EfOM　and　NOM.　The　molecular　weight　distribution　as　well　as　EEM　analysis　demonstrated　the　dissimilar　characteristics　of　EfOM　and　NOM,　which　caused　the　different　treatment　efficiency　by　preozonation　and　CNT　modification.　The　mechanism　of　EfOM/NOM　fouling　on　LPM　was　summarized　as　the　primary　blocking　by　medium-MW　EfOM/NOM.　CNTs　modification　had　a　better　effect　on　the　control　of　LPM　fouling　when　treating　EfOM,　as　it　removed　the　medium-MW　EfOM　by　adsorption　and　prevented　the　pores　blockage　of　the　original　PVDF　membrane.　Preozonation　had　a　better　effect　on　the　control　of　LPM　fouling　when　treating　NOM,　as　it　greatly　changed　the　MWD　of　NOM　by　removing　medium-MW　NOM.　The　combination　effect　of　the　hybrid　preozonation　and　CNTs　modification　resulted　in　the　most　effective　fouling　control　of　LPM　by　both　decreasing　the　medium-MW　and　large-MW　EfOM/NOM.　At　the　same　time,　it　decreased　irreversible　fouling　related　with　membrane　pore　blocking.　The　hybrid　approach　demonstrated　its　promising　application　for　LPM　fouling　control　in　actual　sewage　water　and　surface　water　treatment　process.