Uniting　combinational　strategies　has　been　confirmed　to　be　a　robust　choice　for　high-performance　cancer　treatment　due　to　their　abilities　to　overcome　tumor　heterogeneity　and　complexity.　However,　the　development　of　a　simple,　effective,　and　multifunctional　theranostics　nanoplatform　still　remains　a　challenge.　In　this　study,　we　integrated　multicomponent　hyaluronic　acid　(HA),　protamine　(PS),　nanodiamonds　(NDs),　curcumin　(Cur),　and　IR780　into　a　single　nanoplatform　(denoted　as　HPNDIC)　based　on　the　combination　of　hydrophobic　and　electrostatic　noncovalent　interactions　for　dual-modal　fluorescence/photoacoustic　imaging　guided　ternary　collaborative　Cur/photothermal/photodynamic　combination　therapy　of　triple-negative　breast　cancer　(TNBC).　A　two-step　coordination　assembly　strategy　was　utilized　to　realize　this　purpose.　In　the　first　step,　PS　was　utilized　to　modify　the　NDs　clusters　to　form　positively　charged　PS@NDs　(PND)　and　the　simultaneous　encapsulation　of　the　natural　small-molecule　drug　Cur　and　the　photosensitive　small-molecule　IR780　(PNDIC).　Second,　HA　was　adsorbed　onto　the　outer　surface　of　the　PNDIC　through　charge　complexation　for　endowing　a　tumor-targeting　ability　(HPNDIC).　The　resulting　HPNDIC　had　a　uniform　size,　high　drug-loading　ability,　and　excellent　colloidal　stability.　It　was　found　that　under　the　near-infrared　irradiation　condition,　IR780　could　be　triggered　to　exhibit　both　PTT/PDT　dual-pattern　therapy　effects,　leading　to　an　enhanced　therapy　efficiency　of　Cur　both　in　vitro　and　in　vivo　with　good　biocompatibility.　Due　to　the　intrinsic　imaging　property　of　IR780,　the　biodistribution　and　accumulation　behavior　of　HPNDIC　in　vivo　could　be　monitored　by　dual-modal　fluorescence/photoacoustic　imaging.　Taken　together,　our　current　work　demonstrated　the　assembly　of　a　NDs-based　multicomponent　theranostic　platform　for　dual-modal　fluorescence/photoacoustic　imaging　guided　triple-collaborative　Cur/photothermal/photodynamic　against　TNBC.