The　introduction　of　3D　printing　into　the　manufacturing　of　ceramic　components　offers　new　possibilities　to　fabricate　porous　bioceramic　scaffold　with　biomimetic　morphology,　customized-designed　shape　and　suitable　mechanical　property　for　bone　tissue　engineering.　However,　most　of　3D　printed　porous　ceramic　scaffolds　are　prepared　from　the　array　of　unit　cells,　which　do　not　exploit　the　whole　potential　of　additive　manufacturing.　In　this　paper,　a　novel　biomimetic　porous　beta-tricalcium　phosphate　(β-TCP)　scaffolds　with　trabecular-like　morphology　were　obtained　based　on　three　dimension　(3D)　Voronoi　tessellation　method　and　generated　design.　This　bionic　pore　structure　is　fabricated　via　photopolymer-based　digital　light　processing　(DLP)　3D　printing　technique,　a　suitable　30　wt%　β-TCP　ceramic　slurry　with　the　addition　of　adjuvants　was　prepared.　After　optimized　debinding-sintering　process　according　the　TG-DSC　analysis,　the　β-TCP　scaffolds　showed　fully　interconnected　trabecular-like　pore　structure　with　tailorable　pore　size　(360　μm–1200　μm)　and　porosity　(45%–75%)　and　compact　microstructure.　Combining　compressive　tests　and　finite　element　analysis　(FEA),　the　relationship　between　inputting　parameters,　pore　structure　and　compressive　strength　is　investigated.　Thus,　the　mechanical　strength　of　the　trabecular-like　β-TCP　scaffolds　could　be　predicted　and　tuned　in　the　initial　generated　design　stage.　In　addition,　the　shrinkage　ratio　and　XRD　pattern　are　also　detected.　The　method　proposed　in　this　study　may　provide　an　efficient　bionic　design　intended　for　tissue　engineering　applications.　©　2021　Elsevier　Ltd　and　Techna　Group　S.r.l.