Microplastics　(MPs)　and　pharmaceuticals　are　common　emerging　pollutants　in　sewage,　and　their　coexistence　may　have　more　negative　effects　on　the　environments.　This　study　chose　tetracycline　(TC),　ampicillin　(AMP)　and　tridosan　(TCS)　to　investigate　the　responses　of　antibiotic　resistance　genes　(ARGs)　and　microbial　communities　on　different　MPs　(polyvinyl　chloride　(PVC),　polyethylene　(PE))　biofilms　(plastisphere).　The　adsorption　capacity　of　three　pharmaceuticals　on　PVC　and　PE　decreased　in　the　order　of　AMP　＞　IC　＞　TCS.　PE　was　more　conducive　to　microbial　attachment　than　PVC.　MPs　led　to　the　increase　of　the　total　copies　of　ARGs　and　mobile　genetic　elements　(MGEs)　in　the　sewage.　Importantly,　multidrug　ARGs　and　MGEs　were　enriched　on　plastisphere.　Furthermore,　the　co-occurrence　of　IC　and　MPs　led　to　higher　risks　of　spreading　ARGs　and　MGEs.　In　addition,　potential　pathogenic　bacteria　Legionella,　Mycobacterium,　Neisseria　and　Arcobacter　were　more　abundant　on　plastisphere　than　those　in　sewage,　and　these　bacteria　might　be　the　hosts　for　ARGs　and　MGEs.　This　study　showed　that　plastisphere　could　be　repositories　of　ARGs　and　MGEs　in　sewage　and　accumulated　potential　pathogenic　bacteria.　(C)　2021　Elsevier　B.V.　All　rights　reserved.