Microplastics　(MPs)　and　antibiotic　resistance　genes　(ARGs),　as　emerging　pollutants,　are　frequently　detected　in　wastewater　treatment　plants,　and　their　threats　to　the　environment　have　received　extensive　attentions.　However,　the　effects　of　MPs　on　the　nitrification　of　aerobic　granular　sludge　(AGS)　and　the　spread　patterns　of　intracellular　and　extracellular　ARGs　(iARGs　and　eARGs)　in　AGS　were　still　unknown.　In　this　study,　the　responses　of　AGS　to　the　exposure　of　1,　10　and　100　mg/L　of　typical　MPs　(polyvinyl　chloride　(PVC),　polyamide　(PA),　polystyrene　(PS)　and　polyethylene　(PE))　and　tetracycline　were　focused　on　in　3　L　nitrifying　sequencing　batch　reactors.　10　mg/L　MPs　decreased　the　nitrification　function,　but　nitrification　could　recover.　Furthermore,　MPs　inhibited　ammonia　oxidizing　bacteria　and　enriched　nitrite-oxidizing　bacteria,　leading　partial　nitrification　to　losing　stability.　PVC,　PA　and　PS　stimulated　the　secretion　of　extracellular　polymeric　substances　and　reactive　oxygen　species.　PE　had　less　negative　effect　on　AGS　than　PVC,　PA　and　PS.　The　abundances　of　iARGs　and　eARGs　(tetW,　tetE　and　intI1)　increased　significantly　and　the　intracellular　and　extracellular　microbial　communities　obviously　shifted　in　AGS　system　under　MPs　stress.　Potential　pathogenic　bacteria　might　be　the　common　hosts　of　iARGs　and　eARGs　in　AGS　system　and　were　enriched　in　AGS　and　MPs　biofilms.