Nanozymes　have　the　potential　to　replace　natural　enzymes,　so　they　are　widely　used　in　energy　conversion　technologies　such　as　biosensors　and　signal　transduction　(converting　biological　signals　of　a　target　into　optical,　electrical,　or　metabolic　signals).　The　participation　of　nucleic　acids　leads　nanozymes　to　produce　richer　interface　effects　and　gives　energy　conversion　events　more　attractive　characteristics,　creating　what　are　called　＂functional　nanozymes＂.　Since　different　nanozymes　have　different　internal　structures　and　external　morphological　characteristics,　functional　modulation　needs　to　be　compatible　with　these　properties,　and　attention　needs　to　be　paid　to　the　influence　of　nucleic　acids　on　nanozyme　activity.　In　this　review,　＂functional　nanozymes＂　are　divided　into　three　categories,　(nanozyme　precursor　ion)/(nucleic　acid)　self-assembly,　nanozyme-nucleic　acid　irreversible　binding,　and　nanozyme-nucleic　acid　reversible　binding,　and　the　effects　of　nucleic　acids　on　modulation　principles　are　summarized.　Then,　the　latest　developments　of　nucleic　acid-modulated　nanozymes　are　reviewed　in　terms　of　their　use　in　energy　conversion　technology,　and　their　conversion　mechanisms　are　critically　discussed.　Finally,　we　outline　the　advantages　and　limitations　of　＂functional　nanozymes＂　and　discuss　the　future　development　prospects　and　challenges　in　this　field.