The　Ni-loaded　cryptomelane-type　manganese　oxide　octahedral　molecular　sieve　(OMS-2)　catalysts　(xNi/OMS-2:　x　=　1,　3,　5,　and　10　wt%)　were　prepared　by　a　pre-incorporation　method.　Physicochemical　properties　of　the　as-synthesized　materials　were　characterized　by　means　of　various　techniques,　and　their　catalytic　activities　for　CO,　ethyl　acetate,　and　toluene　oxidation　were　evaluated.The　loading　of　Ni　played　an　important　role　in　improving　physicochemical　propertiesof　OMS-2.　Among　all　of　the　samples,　5Ni/OMS-2　exhibited　the　best　catalytic　activity,　with　the　T-90　being　155　degrees　C　for　CO　oxidation　at　a　space　velocity　(SV)　of　60,000　mL/(g　center　dot　h),　225　degrees　C　for　ethyl　acetate　oxidation　at　an　SV　of　240,000　mL/(g　center　dot　h),　and　300　degrees　C　for　toluene　oxidation　at　an　SV　of　240,000　mL/(g　center　dot　h),　which　was　due　to　its　high　Mn3+　content　and　O-ads　concentration,　good　low-temperature　reducibility　and　lattice　oxygen　mobility,　and　strong　interaction　between　the　Ni　species　and　the　OMS-2　support.　In　addition,　catalytic　mechanisms　of　the　oxidation　of　three　pollutants　over　5Ni/OMS-2　were　also　studied.　The　oxidation　of　CO,　ethyl　acetate,　and　toluene　over　the　catalysts　took　place　first　via　the　activated　adsorption,　then　intermediates　formation,　and　finally　complete　conversion　of　the　formed　intermediates　to　CO2　and　H2O.