Port-hinterland　transport　is　a　freight　transport　mode　that　links　ports　and　inland　destinations　and　contributes　to　a　large　portion　of　the　total　CO2　emissions　from　the　entire　port-related　logistic　chain.　Infrastructure　development　is　conducive　to　reducing　transport　emissions.　However,　decision　making　regarding　the　development　of　port-hinterland　transport　infrastructures　is　complicated　because　port　throughputs　for　different　types　of　cargo　change　with　economic　structural　changes　(ESCs)　in　the　port＇s　hinterland.　Therefore,　this　study　develops　a　hybrid　econometric　and　system　dynamic　model　to　explore　the　impact　of　ESCs　in　the　hinterland　on　a　port＇s　throughput　and　to　formulate　suitable　infrastructure　decisions　to　reduce　CO2　emissions　from　port-hinterland　transport.　The　hybrid　model　is　applied　to　the　Qingdao　port　and　its　hinterland　transport　in　Shandong　Province,　China.　The　results　show　that　long-term　CO2　emissions　from　port-hinterland　transport　will　increase　significantly　because　Shandong＇s　ESCs　will　lead　to　a　notable　increase　in　the　freight　volume　of　containers,　despite　a　concurrent　decrease　in　the　freight　volume　of　iron　ore.　To　reduce　port-hinterland　transport　emissions　under　ESCs,　facilitating　railway　transport　for　containers　prioritizes　over　other　options.　The　results　also　reveal　that　whether　the　ESCs　are　considered　will　lead　to　different　infrastructure　decisions,　and　whether　life-cycle　emissions　of　infrastructure　are　considered　may　lead　to　different　priorities　of　infrastructure　options.　The　findings　indicate　that　holistic　view　and　collaboration　among　government　entities　and　transport-related　stakeholders　should　be　emphasized　in　the　decision　making　of　transport　infrastructure　development.