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The dynamic coupling of stent degradation and vessel remodeling can influence not only the structural morphology and material property of stent and vessel, but also the development of in-stent restenosis. The research achievements of biomechanical modelling and analysis of stent degradation and vessel remodeling were reviewed; several noteworthy research perspectives were addressed, a stent-vessel coupling model was developed based on stent damage function and vessel growth function, and then concepts of matching ratio and risk factor were established so as to evaluate the treatment effect of stent intervention, which may lay the scientific foundation for the structure design, mechanical analysis and clinical application of biodegradable stent.支架降解与血管重建之间形成的动态耦合关系,不仅影响到支架和血管的结构形态和力学性能,而且影响到支架内再狭窄的形成。本文介绍了支架降解和血管重建方面的生物力学建模分析研究成果;提出了若干值得关注的研究前景问题,建立了基于支架损失函数和血管生长函数的支架-血管动态耦合模型,同时提出了匹配度和风险系数的概念,用于评测支架治疗效果,这将为可降解支架的结构设计、力学分析和临床应用打下科学基础。.
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