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作者:

Wu Mixia (Wu Mixia.) | Zhang Xiaoyu (Zhang Xiaoyu.) | Zhang Wei (Zhang Wei.) | Zhang Xu (Zhang Xu.) | Liu Aiyi (Liu Aiyi.)

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摘要:

This article concerns evaluating the effectiveness of a continuous diagnostic biomarker against a continuous gold standard that is measured with error. Extending the work of Obuchowski (2005, 2016), Wu et al (2016) suggested an accuracy index and proposed an estimator for the index with error-prone standard when the reliability coefficient is known. Combining with additional measurements (without measurement errors) on the continuous gold standard collected from some subjects, this article proposes two adaptive estimators of the accuracy index when the reliability coefficient is unknown, and further establish the consistency and asymptotic normality of these estimators. Simulation studies are conducted to compare various estimators. Data from an intervention trial on glycemic control among children with type 1 diabetes are used to illustrate the proposed methods.

关键词:

adaptive estimation additive errors asymptotic normality biomarkers diagnostic accuracy measurement errors reliability coefficient

作者机构:

  • [ 1 ] [Wu Mixia]College of Statistics and Data Science, Beijing University of Technology, Beijing, China
  • [ 2 ] [Zhang Xiaoyu]College of Statistics and Data Science, Beijing University of Technology, Beijing, China
  • [ 3 ] [Zhang Wei]LSC, NCMIS, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China
  • [ 4 ] [Zhang Xu]College of Statistics and Data Science, Beijing University of Technology, Beijing, China
  • [ 5 ] [Liu Aiyi]Biostatistics and Bioinformatics Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

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来源 :

Statistics in medicine

ISSN: 1097-0258

年份: 2021

期: 4

卷: 40

页码: 1034-1058

2 . 0 0 0

JCR@2022

ESI高被引阀值:6

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WoS核心集被引频次: 0

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