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Author:

Li, Bao (Li, Bao.) | Xu, Ke (Xu, Ke.) | Liu, Jincheng (Liu, Jincheng.) | Mao, Boyan (Mao, Boyan.) | Li, Na (Li, Na.) | Sun, Hao (Sun, Hao.) | Zhang, Zhe (Zhang, Zhe.) | Zhao, Xi (Zhao, Xi.) | Yang, Haisheng (Yang, Haisheng.) | Zhang, Liyuan (Zhang, Liyuan.) | Du, Tianming (Du, Tianming.) | Du, Jianhang (Du, Jianhang.) | Liu, Youjun (Liu, Youjun.) (Scholars:刘有军)

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Scopus SCIE PubMed

Abstract:

Traditional enhanced external counterpulsation (EECP) used for the clinical treatment of patients with coronary heart disease only assesses diastolic/systolic blood pressure (Q = D/S > 1.2). However, improvement of the hemodynamic environment surrounding vascular endothelial cells of coronary arteries after long-term application of EECP is the basis of the treatment. Currently, the quantitative hemodynamic mechanism is not well understood. In this study, a standard 0D/3D geometric multi-scale model of the coronary artery was established to simulate the hemodynamic effects of different counterpulsation modes on the vascular endothelium. In this model, the neural regulation caused by counterpulsation was thoroughly considered. Two clinical trials were carried out to verify the numerical calculation model. The results demonstrated that the increase in counterpulsation pressure amplitude and pressurization duration increased coronary blood perfusion and wall shear stress (WSS) and reduced the oscillatory shear index (OSI) of the vascular wall. However, the impact of pressurization duration was the predominant factor. The results of the standard model and the two real individual models indicated that a long pressurization duration would cause more hemodynamic risk areas by resulting in excessive WSS, which could not be reflected by the change in the Q value. Therefore, long-term pressurization during each cardiac cycle therapy is not recommended for patients with coronary heart disease and clinical treatment should not just pay attention to the change in the Q value. Additional physiological indicators can be used to evaluate the effects of counterpulsation treatment.

Keyword:

enhanced external counterpulsation hemodynamic effects 0D/3D geometric multi-scale model vascular endothelial cells coronary artery

Author Community:

  • [ 1 ] [Li, Bao]Beijing Univ Technol, Dept Biomed Engn, Beijing, Peoples R China
  • [ 2 ] [Xu, Ke]Beijing Univ Technol, Dept Biomed Engn, Beijing, Peoples R China
  • [ 3 ] [Liu, Jincheng]Beijing Univ Technol, Dept Biomed Engn, Beijing, Peoples R China
  • [ 4 ] [Li, Na]Beijing Univ Technol, Dept Biomed Engn, Beijing, Peoples R China
  • [ 5 ] [Sun, Hao]Beijing Univ Technol, Dept Biomed Engn, Beijing, Peoples R China
  • [ 6 ] [Yang, Haisheng]Beijing Univ Technol, Dept Biomed Engn, Beijing, Peoples R China
  • [ 7 ] [Zhang, Liyuan]Beijing Univ Technol, Dept Biomed Engn, Beijing, Peoples R China
  • [ 8 ] [Du, Tianming]Beijing Univ Technol, Dept Biomed Engn, Beijing, Peoples R China
  • [ 9 ] [Liu, Youjun]Beijing Univ Technol, Dept Biomed Engn, Beijing, Peoples R China
  • [ 10 ] [Mao, Boyan]Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China
  • [ 11 ] [Zhang, Zhe]Peking Univ Third Hosp, Dept Cardiac Surg, Beijing, Peoples R China
  • [ 12 ] [Zhao, Xi]Philips China Investment Co, Shanghai, Peoples R China
  • [ 13 ] [Du, Jianhang]Sun Yat Sen Univ, Affiliated Hosp 8, Shenzhen, Peoples R China

Reprint Author's Address:

  • 刘有军

    [Liu, Youjun]Beijing Univ Technol, Dept Biomed Engn, Beijing, Peoples R China

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Source :

FRONTIERS IN PHYSIOLOGY

ISSN: 1664-042X

Year: 2021

Volume: 12

4 . 0 0 0

JCR@2022

ESI Discipline: BIOLOGY & BIOCHEMISTRY;

ESI HC Threshold:84

JCR Journal Grade:1

Cited Count:

WoS CC Cited Count: 15

SCOPUS Cited Count: 20

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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