The　addition　of　3%　of　CeO2　improved　the　NH3　adsorption　performance,　the　NO　oxidation,　low　temperature　NO　conversion,　and　the　sulfur　and　water-resistance　of　the　V2O5-WO3/TiO2　catalyst,　established　a　protective　layer　against　catalyst　poisoning.　With　the　increase　in　the　regeneration　temperature　and　time,　the　deactivation　rate　gradually　increased,　and　the　layered　filling　could　slow　down　the　catalyst＇s　overall　deactivation　rate.　In　addition,　the　BET,　SEM,　XRD,　FT-IR,　XPS,　TG,　H2-TPR,　and　NH3-TPD　results　showed　that　the　upper　layer　catalyst　first　contacted　the　SO2　and　H2O　in　the　flue　gases,　leading　to　the　deposition　of　by-products　containing　NH4+　and　SO42−　at　the　highest　level　in　this　catalyst　layer.　Also,　the　decrease　in　the　specific　surface　area　and　pore　volume　was　most　obvious.　The　experiment　selected　the　NH4+　and　SO42−　deposition　amounts　as　characteristic　indices　for　judging　the　catalyst　poisoning　degree,　and　they　also　revealed　the　catalytic　reaction　path　of　the　CeO2　on　the　surface　of　the　V2O5-WO3/TiO2　catalyst.　©　2020　Elsevier　B.V.