In　vivo　optogenetics　provide　special　and　powerful　capabilities　in　regulation　of　neurons,　research　of　neural　circuits　and　even　in　treatment　of　brain　diseases.　However,　conventional　hardware　for　such　studies　tethers　the　experimental　animals　to　remote　light　sources,　power　sources,　or　other　functional　modules,　which　imposes　considerable　physical　constrains　on　natural　behaviors　and　limits　the　range　of　the　experiment.　To　enable　flexible　and　convenient　optogenetic　manipulation　of　neural　circuit　with　finite　disruption　of　animal　behavior,　a　wireles　sly　powered　optoelectronic　device,　composing　mainly　of　a　radio　frequency　(RF)　energy　harvester　and　a　high-performance　GaN-based　light-emitting　diode　(LED),　is　demonstrated　and　can　be　used　to　construct　an　implantable　optrode　for　optogenetics.　The　wireless　RF　power　signal　is　collected　through　an　antenna　and　a　two-stage　voltage　doubling　rectifier　circuit,　and　finally　converted　into　high-amplitude　DC　voltage.　Provided　with　25-dBm　RF　power　with　a　distance　of　0.2　m,　the　RF　energy　harvesting　and　processing　circuit　can　output　a　stable　2.81　V　DC　voltage　and　drive　the　designed　GaN-based　LED　to　work　normally.　After　being　successfully　lit,　the　emission　peak　wavelength　of　the　LED　locates　455　nm　and　the　output　optical　power　density　reaches　214.9　mW/mm(2),　which　is　fully　capable　of　activating　light-sensitive　ion　channel　channelrhodopsin-2.　The　total　area　of　the　device　is　3　mm　x　3.2　mm,　which　is　suitable　for　subdermal　implantation.　(C)　2021　Society　of　Photo　Optical　Instrumentation　Engineers　(SPIE)