Peroxynitrite　(ONOO-)　is　a　cytotoxicant　with　strong　oxidizing　and　nitrating　properties　toward　various　biomolecules,　including　amino　acids,　DNA,　lipids　and　proteins,　thus　can　cause　cell　death,　carcinogenesis　or　aging.　The　aim　of　this　study　was　to　investigate　whether　water-soluble　propolis　extracts　(WSPE)　could　scavenge　peroxynitre　and　further　inhibit　peroxynitrite-mediated　tyrosine　nitration,　DNA　strand　breaks　and　low　density　lipoprotein　(LDL)　oxidation.　The　results　show　that　WSPE　have　a　strong　ability　to　scavenge　ONOO-,　and　its　inhibition　on　ONOO-　exhibited　a　concentration-dependent　manner.　It　is　suggested　that　propolis　extracts　might　be　developed　as　an　effective　peroxynitrite　inhibitor　for　the　prevention　of　ONOO-　involved　diaseses.