Chemical　oxygen　demand　(COD)　and　biochemical　oxygen　demand　(BOD)　with　irreplaceable　significance　are　comprehensive　indicators　for　evaluating　water　quality.　Effective　control　of　water　pollution　depends　on　the　rapid　determination　of　these　indicators.　In　the　study,　the　rapid　determination　of　BOD　was　carried　out　by　activated　sludge　aeration　degradation　method.　The　BOD　quantification　was　achieved　by　measuring　the　COD　change　before　and　after　microbial　degradation　(BOD.COD).　Single-factor　experiment　was　employed　to　investigate　the　effect　of　operating　parameters　on　the　determination　of　BOD.　In　addition,　the　interactions　of　main　variables　were　evaluated　by　Box-Behnken　Design,　and　the　results　showed　that　the　interaction　term　of　reaction　time　and　initial　pH　value　had　a　significant　effect.　The　optimum　conditions　for　determination　of　BOD　were　reaction　time　of　273.68　min,　dosage　of　activated　sludge　of　8.72　mL,　and　pH　of　7.18.　Under　the　optimal　conditions,　the　correlation　experiment　showed　that　BOD.COD　and　BOD　5　exhibited　a　good　linear　relationship　in　the　concentration　range　of　0-500　mg/L,　and　the　correlation　coefficient　R-2　was　0.996.　It　indicated　that　the　method　realized　not　only　the　rapid　determination　of　BOD,　but　also　the　integrated　determination　of　COD　and　BOD.