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作者:

Qiao, Yuanhua (Qiao, Yuanhua.) (学者:乔元华) | Jia, Erze (Jia, Erze.) | Zeng, Yanjun (Zeng, Yanjun.)

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CPCI-S

摘要:

In an effort to facilitate alternative splicing discovery, methods for facilitating the prediction of various types of alternative splicing have been developed. So far, efficient computational approach has not been developed for the prediction of various types of alternative splicing patterns that occur widely in human genome as well as in other organism. Some of splicing alternative exons, such as alternatively spliced internal type, have some combination of characteristics which make it easy to distinguish from constitutive exons. This work explores the use of EM algorithm, Gibbs sampling and support vector machine (SVM), for alternatively spliced internal Exons prediction. Its prediction accuracy was evaluated by using an independent set of exons and by comparison with results obtained from other commonly used classification method (Logistic regression analysis) using the same dataset. The accuracy of the prediction is 83.6%, which is comparable to the results obtained by other classification method.

关键词:

alternatively spliced internal exons EM algorithm Gibbs sampling SVM

作者机构:

  • [ 1 ] [Qiao, Yuanhua]Beijing Univ Technol, Coll Appl Sci, Beijing 100022, Peoples R China

通讯作者信息:

  • 乔元华

    [Qiao, Yuanhua]Beijing Univ Technol, Coll Appl Sci, Beijing 100022, Peoples R China

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来源 :

PROGRESS ON POST-GENOME TECHNOLOGIES

年份: 2007

页码: 115-118

语种: 英文

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