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作者:

Ruan Xiao-Gang (Ruan Xiao-Gang.) | Wang Jin-Lian (Wang Jin-Lian.) | Li Jian-Geng (Li Jian-Geng.)

收录:

PubMed

摘要:

Computational analysis is essential for transforming the masses of microarray data into a mechanistic understanding of cancer. Here we present a method for finding gene functional modules of cancer from microarray data and have applied it to colon cancer. First, a colon cancer gene network and a normal colon tissue gene network were constructed using correlations between the genes. Then the modules that tended to have a homogeneous functional composition were identified by splitting up the network. Analysis of both networks revealed that they are scale-free. Comparison of the gene functional modules for colon cancer and normal tissues showed that the modules' functions changed with their structures.

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作者机构:

  • [ 1 ] [Ruan Xiao-Gang]Institute of Artificial Intelligence and Robotics, School of Electronic Information & Control Engineering, Beijing University of Technology, Beijing 100022, China

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来源 :

Genomics, proteomics & bioinformatics

ISSN: 1672-0229

年份: 2006

期: 4

卷: 4

页码: 245-52

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