The　photocatalytic　decomposition　is　a　highly　efficient　method　for　removing　environmental　pollution.　Reduced　graphene　oxide　(rGO)　loaded　HoVO4-TiO2　was　prepared　hydrothermally　and　characterized　by　XRD,　FE-SEM,　EDX,　TEM,　XPS,　FT-Raman　spectral　analysis,　FT-IR　and　UV-DRS.　The　powder　XRD　confirmed　the　formation　of　the　anatase　structure　of　the　TiO2　and　monoclinic　scheelite　structure　of　HoVO4.　FE-SEM　images　of　rGO-HoVO4-TiO2　depicted　a　mixed　needle　and　spherical　structure.　DRS　spectra　of　rGO　and　HoVO4　in　rGO-HoVO4-TiO2　composite　increased　its　visible　absorbance　region.　The　photocatalytic　study　revealed　an　enhanced　photodecomposition　efficiency　of　rGO-HoVO4-TiO2　composite　material　than　HoVO4,　TiO2,　rGO-HoVO4,　rGO-TiO2　at　pH　7　in　the　removal　of　ibuprofen.　The　effects　of　operational　parameters　such　as　the　catalyst　amount,　ibuprofen　concentration　have　been　analyzed　and　compared　with　the　previous　reports.　The　degradation　mechanism　is　proposed　for　ibuprofen　under　visible　light　illumination.　Moreover,　the　rGO-HoVO4-TiO2　catalyst　has　excellent　stability　and　the　photocatalytic　decomposition　of　ibuprofen　mainly　depends　on　superoxide　radicals　photogenerated　from　rGO-HoVO4-TiO2　under　visible　light　illumination.　The　antibacterial　activity　was　investigated　against　Staphylococcus　aureus,　staphylococcus　pyogenes,　Bacillus　subtilis,　and　Escherichia　coli　and　the　catalyst　has　good　to　moderate　activity.