Inspired　by　recent　advancements　and　owing　to　their　low　weight,　flexible　design,　and　acceptable　cushioning　and　shock　absorption,　micmcellular　foams　are　being　widely　utilized　in　the　automotive,　helmet,　aerospace,　and　transportation　packaging　fields.　Herein,　we　research　the　relationship　between　the　mechanical　properties　of　microcellular　foams　and　their　meso-structure.　This　study　combines　static　mechanical　property　tests　with　numerical　simulations　to　analyze　and　predict　the　effects　of　different　void　porosities,　cell　sizes,　and　cell　morphologies　on　the　static　compressive　properties　of　polymethyl-methacrylate　(PMMA)　microcellular　foams.　It　was　determined　that　the　void　porosity　of　the　foam　had　the　most　significant　influence　on　the　static　compression　performance.　For　foams　with　the　same　average　cell　size　(7　+/-　1　mu　m),　the　compressive　strength　increased　by　144%　(the　void　porosity　was　from　65%　to　37%);　for　foams　with　the　same　void　porosity　(64　+　1%),　the　compressive　strength　increased　by　42%　(the　average　cell　size　was　from　21　mu　m　to　8　mu　m).　The　cell　morphology　had　the　least　influence　on　the　static　mechanical　properties.　The　ellipsoidal　cells　had　a　superior　compression　performance　compared　to　the　spherical　and　the　polyhedral　cells;　the　compressive　strength　increased　by　8.2%.