There　are　many　digital　signal　processing　algorithms　used　in　processing　biomedical　signals.　In　a　typical　biomedical　engineering　design　course,　normally　students　have　limited　design　opportunity.　In　order　to　improve　the　teaching　effect,　here　at　the　Beijing　University　of　Technology,　the　＂Biomedical　signal　processing＂　laboratory　setups　were　designed　with　project-based　learning　on　MATLAB　language,　which　has　simple　grammar,　rich　graphic　displaying　function　and　powerful　toolboxes　for　various　signal　processing　algorithms.　Two　representative　projects　of　analyzing　ECG　signals　and　processing　of　brain　MR　images　are　presented　to　illustrate　its　applications　in　different　aspects　of　biomedical　signal　processing.　The　result　showed　that　project-based　learning　with　MATLAB　will　encourage　students　to　have　a　better　undersatnding　of　existing　algorithms　and　boost　the　students＇　learning　curve　in　the　course.