In　present　study,　copper　(Cu),　zinc　(Zn),　tetracycline　(TC)　and　ampicillin　(AMP)　were　selected　to　study　the　individual　and　synergistic　effects　of　antibiotics　and　heavy　metals　on　the　microbial　communities　and　resistance　genes　on　polyvinyl　chloride　microplastics　(PVC　MPs)　and　surrounding　sewage　after　28　and　84　days.　The　results　indicated　that　PVC　MPs　enriched　many　microorganisms　from　surrounding　sewage,　especially　pathogenic　bacteria　such　as　Mycobacterium　and　Aquabacterium.　The　resistance　gene　with　the　highest　abundance　enriched　on　PVC　MPs　was　tnpA　(average　abundance　of　1.0　×　107　copies/mL　sewage).　The　single　presence　of　Zn,　TC　and　AMP　inhibited　these　enrichments　for　a　short　period　of　time　(28　days).　But　the　single　presence　of　Cu　and　the　co-existence　of　antibiotics　and　heavy　metals　inhibited　these　enrichments　for　a　long　period　of　time　(84　days),　resulting　in　relatively　low　microbial　diversities　and　resistance　genes　abundances.　Transpose　tnpA　had　significantly　positive　correlations　(p　©　2020　Elsevier　B.V.