Bisphenol-A　(BPA)　has　been　widely　used　as　a　plasticizer　in　modern　society　and　persistently　released　into　aquatic　environments.　Herein,　a　novel　Fe2O3-graphene　oxide　(GO)　hybrid　containing　22.8%　of　GO　was　prepared　to　enhance　BPA　removal　from　contaminated　water　and　wastewater.　This　hybrid　material　afforded　outstanding　BPA　adsorption　capacities　of　3293.9　mg　g−1　under　optimized　conditions,　which　led　to　1.9　times　and　1.2　times　of　BPA　removal　as　compared　to　GO　and　reduced　GO　(rGO),　respectively.　In　addition,　Fe2O3-GO　showed　higher　thermal　stability,　greater　solid/liquid　separation　performance,　and　better　anti-fouling　performance.　Moreover,　the　coexistence　of　natural　or　effluent　organic　matter　caused　6.7–16.8%　decline　in　BPA　adsorption　capacity　of　Fe2O3-GO,　which　was　lower　than　those　of　GO　and　rGO　(11.8–39.4%).　Further　characterization　experiments　revealed　that　BPA　removal　by　Fe2O3-GO　was　enhanced　because　of　the　formation　of　Lewis　acid-base　(AB)　interactions　between　the　active　sites　on　Fe2O3　(Lewis　base)　and　BPA　anions　(Lewis　acid).　The　existence　of　the　AB　interaction　is　beneficial　for　practical　application　considering　the　low　environmental　concentrations　of　BPA　in　water　and　wastewater.　Besides,　the　distinctly　lowered　GO　content　of　the　hybrid　saved　77.2%　of　the　adsorbent　cost.　In　conclusion,　this　study　demonstrated　the　potential　of　Fe2O3-GO　as　a　novel　material　for　the　treatment　of　BPA-contaminated　water　and　wastewater.　©　2020　Elsevier　Ltd