Based　on　the　mega-columns　in　the　projects　of　China　Zun　and　Tianjin　117　Tower,　4　multi-cell　concrete-filled　steel　tube　mega-column　specimens　were　designed,　and　experimental　study　was　conducted　under　one-way　repeated　eccentric　compression　load.　The　specimens　include　one　1/13　scaled　octagonal　13-cell　model　of　China　Zun,　one　1/13　scaled　octagonal　13-cell　model　of　China　Zun　with　circular　steel　tube　at　corners,　and　two　1/12　scaled　hexagonal　6-cell　models　of　Tianjin　117　Tower.　The　damage　evolution,　bearing　capacity,　deformation　restoration　capacity,　stiffness,　and　degeneration　of　the　specimens　with　different　section　shapes　and　constructions　were　theoretically　analyzed.　Results　show　that　all　the　specimens　had　good　behaviors　under　eccentric　compression.　The　setting　of　octagonal　13-cell　mega-column　with　circular　steel　tube　at　corners　could　effectively　reduce　the　damage　evolution　and　significantly　improve　the　bearing　capacity　and　deformation　capacity.　Higher　bearing　capacity　could　be　obtained　when　the　eccentricity　of　the　hexagonal　6-cell　mega-column　specimen　was　small,　and　the　restoration　capacity　of　the　specimen　was　relatively　good　when　the　eccentricity　was　large.　Various　codes　and　the　fiber　based　method　were　used　to　estimate　the　N-M　interaction　curves　and　F-Δ　curves　of　the　specimens,　and　the　calculation　results　were　more　conservative　compared　with　experimental　results.　Hence,　referring　to　the　features　of　multi-cell　concrete-filled　steel　tube　columns,　a　modified　simplified　calculation　method　for　compressive　strength　of　multi-cell　concrete-filled　steel　tube　(fsc)　was　proposed　on　the　basis　of　the　calculation　method　in　code　GB　50936　and　the　constitutive　relation　of　concrete　proposed　by　Han.　The　calculated　N-M　interaction　curves　and　bearing　capacity　were　in　good　agreement　with　measured　results,　which　suggests　that　the　simplified　method　can　be　used　as　a　reference　for　the　calculation　of　multi-cell　concrete-filled　steel　tube　columns　under　eccentric　compression.　©　2020,　Editorial　Board　of　Journal　of　Harbin　Institute　of　Technology.　All　right　reserved.