Background　and　Objective:　The　series　type　of　LVAD　(i.e.,　BJUT-II　VAD)　is　a　novel　left　ventricular　assist　device,　whose　effects　on　the　aortic　valve　remain　unclear.　Methods:　The　biomechanical　effects　of　BJUT-II　VAD　on　the　aortic　valve　were　investigated　by　using　a　fluidstructure　interaction　method.　The　geometric　model　of　BJUT-II　VAD　was　virtually　implanted　into　the　ascending　aorta　to　generate　the　realistic　flow　pattern　for　the　aortic　valve　(i.e.,　support).　In　addition,　the　biomechanical　states　of　the　aortic　valve　without　BJUT-II　VAD　support　was　computed　as　control　(i.e.,　control　case).　Results:　Results　demonstrated　that　the　biomechanical　effects　of　BJUT-II　VAD　were　quite　different　from　that　resulting　from　traditional　＇bypass　LVAD.＇　Compared　with　those　in　the　control　case,　BJUT-II　VAD　support　could　significantly　reduce　the　stress　load　of　the　leaflet　(maximum　stress,　0.5　MPa　in　the　control　case　vs.　0.12　MPa　in　the　support　case).　Similarly,　the　rapid　valve　opening　time　(100　ms　in　the　control　case　vs.　175　ms　in　the　support　case)　and　rapid　valve　closing　time　(50　ms　in　the　control　case　vs.　150　ms　in　the　support　case)　in　the　support　case　were　obviously　longer　than　those　in　the　control　case.　Moreover,　BJUT-II　VAD　support　reduced　retrograde　blood　flow　during　the　diastolic　phase　and　significantly　changed　the　distribution　of　WSS　of　the　leaflets.　Conclusions:　In　summary,　while　unloading　the　left　ventricle,　BJUT-II　VAD　could　provide　beneficial　biomechanical　states　for　the　aortic　leaflets,　thereby　reducing　the　risk　of　aortic　valve　disease.　©　2020