In　this　paper,　nanoscale　Cu2O　particles　was　successfully　anchored　at　defect　sites　of　carbon　nanotubes　(CNTs),　which　doped　on　three-dimensional　copper　foam　(CF)　electrode　(Cu2O@CNTs/CF).　The　compound　as　cathode　was　synthesized　via　dip-coating　and　rapid　electrodeposition　followed　by　annealing　procedure,　and　conducted　in　heterogeneous　electro-Fenton　(EF)　system.　The　Cu2O@CNTs/CF　composites　electrode　enabled　activate　O-2　to　generate　H2O2　in　situ　and　further　Cu-0/Cu2O　synergistic　catalysis　to　produce　reactive　oxygen　species　for　a　broad　pH-range　via　the　heterogeneous　EF　process.　Cu-0　on　the　surface　of　CF　also　contributed　to　the　reduction　of　Cu2+　to　Cu+,　thereby　enhancing　the　stability　of　the　electrode.　The　effects　of　critical　parameters　such　as　precursorligand　dosage,　the　initial　pH　value,　initial　pollutant　concentration　and　current　density　on　the　degradation　of　the　antibiotic　sulfamethoxazole　(SMX)　were　investigated.　The　as-obtained　electrode　performed　both　effective　catalytic　activity　and　good　reusability.　Almost　100%　removal　rate　was　reached　within　75　min　over　a　broad　pH　range　(3　to　11)　during　the　heterogeneous　EF　process,　with　the　current　density　of　12　mA　cm(-2)　and　the　removal　efficiency　of　SMX　decreased　by　only　9.0%　after　8　recycle　runs.　Furthermore,　quenching　experiments　indicated　that　hydroxyl　radicals　(center　dot　OH)　were　main　species　responsible　for　the　SMX　oxidation.　In　addition,　the　possible　degradation　pathways　of　SMX　were　proposed,　which　were　based　on　nine　identified　intermediates.　The　comprehensivework　is　elucidated　to　accelerate　the　development　of　the　in-situ　production　of　H2O2　during　the　heterogeneous　EF　system　and　provide　new　insights　to　achieve　high-efficiency　degradation　of　pollutants　via　copper-based　catalytic　materials.　(C)　2021　Elsevier　B.V.　All　rights　reserved.