A　new　model　based　on　the　removal　mechanism　of　loose/compact　cake　and　the　re-deposition　mechanism　of　foulants　was　proposed　to　predict　the　instantaneous　fouling　resistance　(Rf(t))　in　the　rinsing　process　of　0.1　mu　m　PAN　membrane　fouled　with　activated　sludge.　The　variation　trend　of　Rf(t)　was　also　analyzed　by　the　removal　rate　of　loose/compact　cake　(rr-ose/rr-compact)　and　the　re-deposition　rate　of　foulants　(rre-deposition).　Moreover,　the　model　was　validated　by　using　other　foulants　(yeast,　actual　activated　sludge,　HA　and　SA)　and　membranes　(0.1　mu　m　PES　and　PVDF　membranes).　The　results　showed　that　the　model　predictions　had　good　agreements　with　experimental　data　at　different　cross-flow　velocities　(1.0,　1.5,　2.0　and　2.5　m/s)　or　temperatures　(25,　30,　35　and　40　degrees　C)　(R2　0.9900).　Besides,　the　variation　trend　of　Rf(t)　could　be　divided　into　three　stages:　(i)　Rf(t)　quickly　decreased　and　the　removal　of　loose　cake　was　almost　completed　at　rinsing　time　of　t1　(first　transition　point)　(rrose　=　0);　(ii)　Rf(t)　slowly　decreased　and　Rf(t)　reached　to　minimum　(rr-compact　=　rre-deposition)　at　t2　(second　transition　point);　(iii)　Rf(t)　slightly　increased　after　t2　(rr-compact(t)＜rre-deposition(t)).　This　model　would　provide　an　accurate　method　to　analyze　the　variation　trend　of　Rf(t)　in　the　rinsing　process　and　a　theoretical　basis　for　the　optimization　of　rinsing　conditions.