Three-dimensionally　ordered　macroporous　(3DOM)　MnCo2O4-supported　Co3O4　and　AuPd　(xAuPdz/yCo3O4/　3DOM　MnCo2O4;　x　=　0.56-1.98　wt%,　z　=　1.9-2.1,　and　y　=　4.80-24.36　wt%)　catalysts　were　prepared　using　polymethyl　methacrylate　(PMMA)　microsphere-templating,　incipient　wetness　impregnation,　and　polyvinyl　alcohol　(PVA)-protected　reduction　methods.　Physicochemical　properties　of　the　materials　were　characterized　by　means　of　numerous　techniques,　and　their　catalytic　activities　were　evaluated　for　methane　combustion.　It　is　found　that　the　xAuPdz/yCo3O4/3DOM　MnCo2O4　samples　with　a　surface　area　of　26.5-53.1　m2/g　possessed　a　highquality　3DOM　architecture,　in　which　the　AuPd　nanoparticles　(NPs)　with　a　size　of　4.6-5.8　nm　were　highly　dispersed　on　the　surface　of　the　macropore　framework.　Among　all　of　the　samples,　1.98AuPd2.1/18.20Co3O4/　3DOM　MnCo2O4　exhibited　the　highest　catalytic　activity:　the　T10%,　T50%,　and　T90%　(temperatures　required　for　achieving　methane　conversions　of　10,　50,　and　90　%,　respectively)　were　262,　340,　and　408　degrees　C　at　a　space　velocity　of　40,000　mL/(g　h).　Partial　deactivation　of　the　1.98AuPd2.1/18.20Co3O4/3DOM　MnCo2O4　sample　due　to　introduction　of　water　vapor　or　carbon　dioxide　was　reversible.　It　is　concluded　that　the　good　catalytic　performance　of　1.98AuPd2.1/18.20Co3O4/3DOM　MnCo2O4　was　associated　with　its　high　adsorbed　oxygen　species　concentration,　good　low-temperature　reducibility,　and　strong　interaction　between　Co3O4　or　AuPd2.1　NPs　and　3DOM　MnCo2O4.