Nitroaromatic　compounds　(NACs)　are　ubiquitous　in　the　environment　due　to　their　extensive　industrial　applications.　The　recalcitrance　of　NACs　causes　their　arduous　degradation,　subsequently　bringing　about　potential　threats　to　human　health　and　environmental　safety.　The　problem　of　how　to　effectively　predict　the　toxicity　of　NACs　has　drawn　public　concern　over　time.　Quantitative　structure-activity　relationship　(QSAR)　is　introduced　as　a　cost-effective　tool　to　quantitatively　predict　the　toxicity　of　toxicants.　Both　OECD　(Organization　for　Economic　Co-operation　and　Development)　and　REACH　(Registration,　Evaluation　and　Authorization　of　Chemicals)　legislation　have　promoted　the　use　of　QSAR　as　it　can　significantly　reduce　living　animal　testing.　Although　numerous　QSAR　studies　have　been　conducted　to　evaluate　the　toxicity　of　NACs,　systematic　reviews　related　to　the　QSAR　modeling　of　NACs　toxicity　are　less　reported.　The　purpose　of　this　review　is　to　provide　a　thorough　summary　of　recent　QSAR　studies　on　the　toxic　effects　of　NACs　according　to　the　corresponding　classes　of　toxic　response　endpoints.