Multiple　variable　frequency　pendulum　isolator　(MVFPI)　has　been　recently　developed　as　a　superior　alternative　to　the　traditional　friction　pendulum　bearing　(FPB)　especially　for　the　seismic　isolation　in　near-fault　regions.　The　MVFPI　is　characterized　by　its　variable　frequency　and　self-adaptability,　which　are　achieved　by　piecewise　function　of　sliding　surface　and　shape　memory　alloy　(SMA).　The　objective　of　this　study　is　to　propose　the　design　algorithm　of　the　MVFPIs　in　highway　bridge　as　an　extension　of　the　direct　displacement-based　design　(DDBD)　framework.　The　nonlinearities　of　the　structural　components　are　taken　into　account　in　the　design　procedure,　and　the　corresponding　damage　states　satisfy　the　two-stage　design　philosophy.　The　accuracy　and　robustness　of　the　design　procedure　are　verified　by　an　isolated　four-span　highway　bridge　through　nonlinear　time　history　(NLTH)　analyses.　The　analytical　results　indicate　that　the　proposed　design　procedure　can　predict　the　profile　of　deck　displacement　and　amplitude,　as　well　as　the　damage　states　of　the　piers.　From　statistic　aspect,　the　fragility　analyses　illustrate　that　the　bridge　isolated　by　MVFPIs　exhibits　better　seismic　performance　than　that　of　the　bridge　isolated　by　FPBs.