This　paper　presents　an　efficient　experimental-numerical　analysis　of　fracture　mechanics　in　magnesium　phosphate　cement　(MPC)　based　on　the　structural　and　mechanical　properties　of　its　constituents　including　potassium　magnesium　phosphate　hexahydrate　(MKP),　magnesium　oxide　(MgO)　and　pores.　At　micro-scale,　the　fracture　energy　and　material　strength　of　solid　phases　were　obtained　relying　on　the　combination　of　nanoindentation　experiments　and　simulation.　The　X-ray　computed　tomography　(XCT)　image-based　3D　meso-structure　model　of　MPC　beam　was　generated　and　incorporated　with　the　finite　element　cohesive　zone　model　to　analyse　the　fracture　process　of　MPC　beam　under　three-point　bending.　The　unknown　fracture　parameters　of　cohesive　elements　at　the　interface　between　MKP　and　MgO　were　determined　via　the　model　calibration　process　conditional　to　the　experimental　data　in　terms　of　relationship　between　macro-load　and　crack　mouth　opening　displacement.　The　cohesive　strengths　obtained　for　MKP,　MgO　and　MKP-MgO　were　found　to　be　5.8,　106　and　24　MPa,　respectively.　In　the　same　order,　the　fracture　energies　were0.02,　0.08　and　0.04　N/mm,　respectively.