In　this　study,　an　innovative　hollow-core　cross-laminated　timber　(HC-CLT)　system　was　examined　in　terms　of　its　human-induced　vibration　performance.　Three　types　of　HC-CLT　floors　were　selected　as　the　research　objects,　namely　3-ply　HC-CLT,　5-ply　HC-CLT　with　hollow　cores　along　the　transverse　direction,　and　5-ply　HC-CLT　with　hollow　cores　along　the　longitudinal　direction.　By　theoretical　analysis,　it　was　found　that　the　hollow　cores　had　a　slight　impact　on　the　static　bending　stiffness,　and　HC-CLT　floors　had　a　good　potential　for　structural　applications.　The　HC-CLT　floors　were　then　modelled　using　OpenSees　software　to　assess　its　dynamic　performance,　and　experimental　testing　results　have　validated　the　modelling　method.　The　HC-CLT　floors　were　excited　by　single-person,　two-person,　and　five-person　slow　walking,　fast　walking,　and　running.　Based　on　the　recorded　acceleration　at　the　centroid　of　the　floor,　it　was　realised　that　the　vibration　dose　values　(VDV)　of　the　5-ply　HC-CLT　floor　with　hollow　cores　along　the　transverse　direction　were　not　larger　than　those　of　the　solid　CLT　floor　under　walking　excitations.　It　indicated　that　the　hollow　cores　were　more　effective　to　distribute　along　the　transverse　direction　to　assure　the　comfort　level.　However,　the　vibration　response　of　the　HC-CLT　floor　under　running　excitations　was　larger.　By　enhancing　the　beam　supporting　condition　from　the　two-side　to　the　four-side　support,　the　vibration　response　of　the　HC-CLT　floor　can　be　effectively　reduced.