Autophagy　is　a　conserved　degradation　process　crucial　to　maintaining　the　primary　function　of　cellular　and　organismal　metabolism.　Impaired　autophagy　could　develop　numerous　diseases,　including　cancer,　cardiomyopathy,　neurodegenerative　disorders,　and　aging.　N6-methyladenosine　(m6A)　is　the　most　common　RNA　modification　in　eukaryotic　cells,　and　the　fate　of　m6A　modified　transcripts　is　controlled　by　m6A　RNA　binding　proteins.　m6A　modification　influences　mRNA　alternative　splicing,　stability,　translation,　and　subcellular　localization.　Intriguingly,　recent　studies　show　that　m6A　RNA　methylation　could　alter　the　expression　of　essential　autophagy-related　(ATG)　genes　and　influence　the　autophagy　function.　Thus,　both　m6A　modification　and　autophagy　could　play　a　crucial　role　in　the　onset　and　progression　of　various　human　diseases.　In　this　review,　we　summarize　the　latest　studies　describing　the　impact　of　m6A　modification　in　autophagy　regulation　and　discuss　the　role　of　m6A　modification-autophagy　axis　in　different　human　diseases,　including　obesity,　heart　disease,　azoospermatism　or　oligospermatism,　intervertebral　disc　degeneration,　and　cancer.　The　comprehensive　understanding　of　the　m6A　modification　and　autophagy　interplay　may　help　in　interpreting　their　impact　on　human　diseases　and　may　aid　in　devising　future　therapeutic　strategies.