The　degradation　efficiency　of　fulvic　acid　(FA)　was　investigated　in　the　catalytic　wet　oxidation　process　(CWPO)　by　zero-valent　copper　chitosan　activated　carbon　ball　(ZVC/CTS-ACB).　Characterization　of　ZVC/CTS-ACB　shows　that　zero-valent　copper　was　loaded　successfully　on　the　chitosan　activated　carbon.　Plackett-Buiman　(PB)　design　and　response　surface　methodology　(RSM)　were　employed　to　determine　the　influence　factors　and　the　optimum　processing　parameters.　The　model　was　well　fitted　to　the　actual　data　and　the　correlation　coefficients　of　R-2　and　R-2-adj　were　0.9359　and　0.9039,　respectively.　Under　the　obtained　optimum　conditions　for　FA　degradation:　temperature=94　degrees　C　and　pH　3.8,　the　average　FA　removal　by　three　replicate　experiments　was　93.02%,　which　has　a　high　consistency　to　the　RSM　optimal　target　response　of　93.86%.　The　comparison　of　catalytic　performance　showed　that　the　addition　of　catalyst　ZVC/CTS-ACS　could　increase　the　removal　rate　of　FA,　color　number　(CN)　and　TOC　by　93.6%,　83.5%　and　81.9%　respectively.　The　high　TOC　removal　rate　indicated　the　good　performance　of　the　catalyst　to　FA　mineralization.　Additionally,　the　ICP　analysis　of　copper　ion　leaching　was　only　0.08　mg/l　after　5　repeated　recycles　of　the　catalyst,　demonstrating　the　high　stability　of　ZVC/CTS-ACB　that　is　beneficial　for　the　actual　application.