Constructing　stable　palladium(II)-based　metal-organic　frameworks　(MOFs)　would　unlock　more　opportunities　for　MOF　chemistry,　particularly　toward　applications　in　catalysis.　However,　their　availability　is　limited　by　synthetic　challenges　due　to　the　inertness　of　the　Pd-ligand　coordination　bond,　as　well　as　the　strong　tendency　of　the　Pd(II)　source　to　be　reduced　under　typical　solvothermal　conditions.　Under　the　guidance　of　reticular　chemistry,　herein,　we　present　the　first　example　of　an　azolate　Pd-MOF,　BUT-33(Pd),　obtained　via　a　deuterated　solvent-assisted　metal　metathesis.　BUT-33(Pd)　retains　the　underlying　sodalite　network　and　mesoporosity　of　the　template　BUT-33(Ni)　and　shows　excellent　chemical　stability　(resistance　to　an　8　M　NaOH　aqueous　solution).　With　rich　Pd(II)　sites　in　the　atomically　precise　distribution,　it　also　demonstrates　good　performances　as　a　heterogeneous　Pd(II)　catalyst　in　a　wide　application　scope,　including　Suzuki/Heck　coupling　reactions　and　photocatalytic　CO2　reduction　to　CH4.　This　work　highlights　a　feasible　approach　to　reticularly　construct　noble　metal　based　MOFs　via　metal　metathesis,　in　which　various　merits,　including　high　chemical　stability,　large　pores,　and　tunable　functions,　have　been　integrated　for　addressing　challenging　tasks.