Waste　heat　energy　exists　in　the　exhaust,　intercooler,　and　coolant　during　the　operation　of　the　compressed　natural　gas　(CNG)　engine.　The　cascade　utilization　of　the　waste　heat　energy　of　the　CNG　engine　can　be　realized　considering　the　structural　advantages　of　the　dual　loop　organic　Rankine　cycle　(DORC)　system.　Operating　parameters　have　an　important　influence　on　DORC　system　performance.　Traditional　analysis　methods　have　limitations　in　analyzing　the　relationship　between　operating　parameters　and　system　performance,　and　little　attention　is　paid　to　the　environmental　impact　of　the　system.　The　environmental　performance　of　the　system　plays　an　important　role　in　saving　energy　and　protecting　the　environment.　Therefore,　the　bilinear　interpolation　algorithm　is　introduced　to　analyze　the　waste　heat　sources　of　the　CNG　engine　and　the　thermodynamic,　economic,　and　environmental　performances　of　the　DORC　system.　In　addition,　the　comprehensive　operating　performance　of　the　DORC　system　has　not　been　thoroughly　and　comprehensively　optimized.　Therefore,　this　study　proposes　a　multi-model　driven　NSGA-III　method　for　DORC　comprehensive　performance　optimization.　Results　show　that　the　optimal　thermal　efficiency,　payback　period　(PB),　and　emissions　of　CO2　equivalent　(ECE)　are　11.98%,　4.02　years,　and　43.74　ton　CO2,eq,　respectively.　Moreover,　decreasing　the　thermal　efficiency　of　the　system　will　significantly　decrease　ECE　and　increase　PB　at　the　same　time.　This　research　provides　a　reliable　reference　for　the　analysis,　design,　evaluation,　and　optimization　of　the　comprehensive　performance　of　the　DORC　system.