Different　Cu　contents　(x　wt%)　were　supported　on　the　cryptomelane-type　manganese　oxide　octahedral　molecular　sieve　(OMS-2)　(xCu/OMS-2;　x　=　1,　5,　15,　and　20)　via　a　pre-incorporation　method.　Physicochemical　properties　of　the　OMS-2　and　xCu/OMS-2　samples　were　characterized　by　means　of　the　XRD,　FT-IR,　SEM,　TG/DTG,　ICP-OES,　XPS,　O-2-TPD,　H-2-TPR,　and　in　situ　DRIFTS　techniques,　and　their　catalytic　activities　were　measured　for　the　oxidation　of　CO,　ethyl　acetate,　and　toluene.　The　results　show　that　the　Cu　species　were　homogeneously　dispersed　in　the　tunnel　and　framework　structure　of　OMS-2.　Among　all　of　the　samples,　15Cu/OMS-2　sample　exhibited　the　best　activities　with　the　T-50%　of　65,　165,　and　240　degrees　C　as　well　as　the　T-90%　of　85,　215,　and　290　degrees　C　for　CO,　ethyl　acetate　and　toluene　oxidation,　respectively,　which　was　due　to　the　existence　of　the　Cu　species　and　Mn3+/Mn4+　redox　couples,　rich　oxygen　vacancies,　good　oxygen　mobility,　low-temperature　reducibility,　and　strong　interaction　between　the　Cu　species　and　the　OMS-2　support.　The　reaction　mechanisms　were　also　deduced　by　analyzing　the　in　situ　DRIFTS　spectra　of　the　15Cu/OMS-2　sample.　The　excellent　oxygen　mobility　associated　with　the　electron　transfer　between　Cu　species　and　Mn3+/Mn4+　redox　couples　might　be　conducive　to　the　continuous　replenishment　of　active　oxygen　species　and　the　constantly　generated　reactant　intermediates,　thereby　increasing　the　reactant　reaction　rate.