Objective　Renal　sympathetic　denervation　(RDN)　is　an　alternative　treatment　for　resistant　hypertension　(RH).　This　study　aims　to　compare　ablation　effects　using　three　radiofrequency　applicators　(i.e.,　balloon-based　four　electrodes,　spiral　and　monopolar　devices).　Methods　An　idealized　three-dimensional　model　of　the　renal　artery　was　established　using　COMSOL　Multiphysics　to　mimic　radiofrequency　ablation　(RFA).　Radiofrequency　(RF)　energy　was　delivered　to　the　tissue　at　the　same　simulation　settings,　i.e.,　4,　6,　and　8　W　for　60　s,　using　the　three　abovementioned　RF　applicators.　The　temperature　distribution　in　the　tissue　was　calculated　using　the　coupled　electrical-thermal-fluid　finite　element　method.　Lesion　borders　were　defined　using　50　degrees　C　isotherms.　The　maximum　lesion　depth,　width,　area,　and　circumferential　coverage　rate　were　compared　among　the　three　applicators　at　a　blood　flow　of　0.4　m/s.　Monopolar　RF　ablations　in　a　renal　artery　phantom　model　were　performed　to　validate　the　reliability　of　the　simulation　method.　Results　The　balloon-based　system　yields　greater　lesion　depths　and　widths　compared　with　spiral　and　monopolar　denervation　under　the　same　power.　The　range　of　maximum　lesion　depth　is　1.58-3.11　mm　for　balloon-based　RDN,　0.90-1.81　mm　for　spiral　RDN　and　1.12-2.38　mm　for　monopolar　RDN,　at　a　power　of　4-8　W.　The　corresponding　ranges　of　maximum　lesion　width　are　2.22-5.73,　1.48-3.54,　and　1.93-5.31　mm,　respectively,　and　the　circumferential　coverage　rates　of　the　renal　artery　are　41.43%-91.99%,　31.71%-66.23%,　and　9.55%-23.06%,　respectively.　The　average　velocity　after　balloon-based,　spiral,　and　monopolar　RDN　increases　by　3,　5,　and　1　cm/s,　respectively.　The　validation　of　the　computer　model　offered　prediction　errors　are　＜5%　in　terms　of　temperature　at　different　locations　(i.e.,　2,　4,　and　8　mm).　Conclusions　In　terms　of　lesion　size,　balloon-based　RDN　appears　to　be　the　best　option　for　the　treatment　of　RH.　However,　the　change　in　flow　velocity　in　the　arterial　flow　field　suggests　that　its　hemodynamic　changes　must　be　prioritized　for　investigating　its　safety.　Although　spiral　catheter　ablation　yields　the　smallest　lesion　size　and　a　significant　change　in　flow　velocity　in　the　flow　field,　its　coverage　rate　is　larger　than　that　of　monopolar　RDN;　compared　with　balloon-based　RDN,　it　did　not　obstruct　most　of　the　blood　flow.