A　molecularly　imprinted　magnetic　sensor　with　electmluminescent　tags　(MIP-ECL　sensor)　was　developed　for　ultrasensing　diethylstilbestrol　(DES).　A　strategy　is　exploited　to　enhance　ECL　emission　of　the　[Ru(bpy)(3)](2+)-tripropyl　amine　(TPrA)　system　by　CdTe@ZnS　quantum-dots　(QDs)　through　energy　transfer.　Magnetically　molecularly　imprinted　nanoparticles　(MMIPs　NPs)　based　on　Fe3O4@SiO2　carriers　are　artificial,　easily　reproducible,　and　could　replace　easily　inactivated　first　antibodies　for　capturing　more　DES　molecules.　Functionalized　bio-conjugates　of　single　antibody-CdTe@ZnS　(Ab-CdTe@ZnS)　are　for　the　first　time　loaded　on　signal　labels　of　Ru(bpy)　+-doped　silica　nanocomposites　(Ru@SiO2)　for　signal　amplification.　The　final　bio-conjugated　signal　probes　are　denoted　as　Ab-DES/CdTe@ZnS-Ru@SiO2.　MMIPs　beads　that　have　captured　antigens　are　bio-conjugated　with　antibodylabeled　luminescent　probes　by　specific　immunoreactive　reaction,　and　then　the　luminescent　immunocomplex　generates　ECL　signal　on　the　magnetic　electrode.　The　logarithm　of　ECL　intensities　depend　linearly　on　the　logarithm　of　DES　concentrations　in　the　range　from　4.8　x　10(-)(4)　to　36.0　nM　with　a　detection　limit　of　0.025　pM.　This　novel　assay　is　much　more　sensitive　than　other　MIP　sensors,　and　achieves　lower　cost　and　more　enhanced　stability　than　other　immunosensors.　The　sensor　is　significantly　potential　and　has　been　applied　to　DES　detection　in　actual　environment.