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作者:

Wu, Mixia (Wu, Mixia.) | Zhang, Xiaoyu (Zhang, Xiaoyu.) | Zhang, Wei (Zhang, Wei.) | Zhang, Xu (Zhang, Xu.) | Liu, Aiyi (Liu, Aiyi.)

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摘要:

This article concerns evaluating the effectiveness of a continuous diagnostic biomarker against a continuous gold standard that is measured with error. Extending the work of Obuchowski (2005, 2016), Wu et al (2016) suggested an accuracy index and proposed an estimator for the index with error-prone standard when the reliability coefficient is known. Combining with additional measurements (without measurement errors) on the continuous gold standard collected from some subjects, this article proposes two adaptive estimators of the accuracy index when the reliability coefficient is unknown, and further establish the consistency and asymptotic normality of these estimators. Simulation studies are conducted to compare various estimators. Data from an intervention trial on glycemic control among children with type 1 diabetes are used to illustrate the proposed methods.

关键词:

measurement errors adaptive estimation diagnostic accuracy asymptotic normality additive errors biomarkers reliability coefficient

作者机构:

  • [ 1 ] [Wu, Mixia]Beijing Univ Technol, Coll Stat & Data Sci, Beijing, Peoples R China
  • [ 2 ] [Zhang, Xiaoyu]Beijing Univ Technol, Coll Stat & Data Sci, Beijing, Peoples R China
  • [ 3 ] [Zhang, Xu]Beijing Univ Technol, Coll Stat & Data Sci, Beijing, Peoples R China
  • [ 4 ] [Zhang, Wei]Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, LSC, Beijing, Peoples R China
  • [ 5 ] [Liu, Aiyi]Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, NIH, Bethesda, MD USA

通讯作者信息:

  • [Liu, Aiyi]Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, Bethesda, MD 20817 USA

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来源 :

STATISTICS IN MEDICINE

ISSN: 0277-6715

年份: 2020

期: 4

卷: 40

页码: 1034-1058

2 . 0 0 0

JCR@2022

ESI学科: SOCIAL SCIENCES, GENERAL;

ESI高被引阀值:79

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