Hydrophilic　polymer　coatings　can　improve　the　surface　characteristics　of　artificial　implants.　However,　because　they　are　used　in　vivo,　they　inevitably　come　into　contact　with　biomolecules　that　affect　their　interfacial　tribological　properties.　In　this　paper,　the　friction　behaviors　of　poly(vinylphosphonic　acid)　(PVPA)-modified　Ti6Al4V　and　polytetrafluorethylene　balls　were　analyzed　using　albumin,　globulin,　aggrecan,　and　hyaluronic　acid　as　lubricants.　The　interaction　properties　and　dynamic　adsorption　characteristics　of　the　biomolecules　and　PVPA　molecules　were　explored　by　a　quartz　crystal　microbalance　to　identify　the　cause　of　the　friction　difference.　It　was　found　that　protein　molecules　disturbed　the　superlubricity　of　the　PVPA-phosphate-buffered　saline　system　because　of　the　formation　of　a　stable　adsorption　film,　which　replaced　the　interfacial　characteristics　of　the　PVPA　coating.　Polysaccharides,　with　their　excellent　hydration　properties　and　polymer　structure,　had　an　unstable　dynamic　interaction　or　zero　adsorption　with　PVPA　molecules,　and　hardly　changed　the　superlubricity　of　the　PVPA　and　phosphate-buffered-saline　system.　The　influence　mechanism　of　the　specific　friction　of　proteins　and　polysaccharides　was　analyzed.　Interactions　were　observed　among　different　biomolecules.　Polysaccharides　can　potentially　reduce　protein　adsorption.　The　result　of　the　synergistic　regulation　of　the　friction　coefficient　for　PVPA-modified　Ti6Al4V　is　approximately　0.017.　The　results　of　this　study　will　provide　a　theoretical　basis　for　the　use　of　polymer　coatings　in　vivo.