The　membrane　fouling　is　a　notorious　problem　in　the　practical　application　of　separation　membranes.　In　this　study,　a　mixed　matrix　membrane　based　on　the　MOF　BUT-8(A)　and　the　polymer　polydiallyldimethylammonium　chloride　(PDDA)　has　been　prepared　on　a　hydrolyzed　polyacrylonitrile　(HPAN)　substrate　by　the　spinassisted　layer-by-layer　assembly　(spin-LbL)　method.　Thanks　to　the　high　porosity,　high　stability,　moderate　hydrophilicity,　and　electronegative　nature　of　BUT-8(A),　and　the　good　compatibility　between　BUT-8(A)　particles　and　PDDA　polyelectrolytes,　the　prepared　(BUT-8(A)/PDDA)3-HPAN　membrane　showed　high　water　permeances　(over　164　L　m(-2)　h(-1)　MPa-1)　and　high　rejection　rates　(over　91.4%)　for　many　dyes　in　water.　Furthermore,　the　membrane　exhibited　superior　antifouling　performance　in　nanofiltration　(NF)　with　a　high　flux　recovery　rate　(95.5%)　when　humic　acid　(HA)　was　used　as　foulant.　The　high　antifouling　performance　is　resulted　from　tuning　hydrophilicity　and　electronegativity　of　the　membrane　surface.　These　results　suggest　that　the　nanofiltration　performance　of　a　MOF-based　membrane　can　be　well　adjusted　by　a　judicious　choice　of　the　membrane　components　and　fabrication　methods.　(c)　2020　Taiwan　Institute　of　Chemical　Engineers.　Published　by　Elsevier　B.V.　All　rights　reserved.